%0 Journal Article
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%@archivingpolicy denypublisher denyfinaldraft24
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%3 Voltammetric detection.pdf
%X This paper describes the electrochemical behavior of the nitrofurazone (NFZ), in predominantly aqueous medium, in the absence and presence of glutathione (reduced form) (GSH), L-Cysteine (Cys) and O-2 using a highly boron doped diamond electrode (HBDDE). In presence of [Thiol] >= 3.7 x 10(-2) mol L-1 NFZ is directly reduced to RNO-Thiol adducts in an electrochemical process involving two electrons and two protons. On the other side, 02 acts as a RNO2 center dot- scavenger and the velocity constant for the reaction, kO(2), is 60 L mol(-1) s(-1). The process is catalytic and can be used to the analytical determination of NFZ in the range of 9.9 x 10(-7) <= [NFZ] <= 1.1 x 10(-5) mol L-1 at pH 8.0, with sensitivity of 2.2 x 10(6) mu A mol(-1) cm(-2) and detection limit of 3.4 x 10(-7) mol L-1. The analytical parameters were similar to those obtained at pH 4.0 using the direct reduction of NFZ to the respective amine derivative in a process involving six electrons and six protons. The characterization of NFZ global reduction process in aqueous medium and at relative low scan rate, 100 mV s(-1), was only possible due the intrinsic superficial characteristics of the HBDDE, which stabilize the RNO2 center dot- free radical, allowing to work in a large potential window, without losing the RNO2 center dot- oxidation signal.
%8 July
%N 24
%T Voltammetric detection of the interactions between RNO2 circle- and electron acceptors in aqueous medium at highly boron doped diamond electrode (HBDDE)
%@secondarytype PRE PI
%K highly boron doped diamond electrode (HBDDE), nitrofurazone free radical, electronic acceptors, voltammetry and catalytic reaction, NITRO RADICAL-ANION, DNA BASES, DERIVATIVES, NITROIMIDAZOLE, GLUTATHIONE, REACTIVITY, REDUCTION, DRUGS.
%@group
%@group
%@group LAS-INPE-MCT-BR
%@secondarykey INPE-14427-PRE/9511
%@copyholder SID/SCD
%@issn 0013-4686
%2 sid.inpe.br/mtc-m16@80/2006/11.23.11.31.58
%@affiliation Univ Sao Paulo (USP)
%@affiliation Univ Estadual Vale Acarau
%@affiliation Instituto Nacional de Pesquisas Espaciais (INPE)
%@affiliation Univ Sao Paulo (USP)
%B Electrochimica Acta
%P 5080-5086
%4 sid.inpe.br/mtc-m16@80/2006/11.23.11.31
%D 2006
%V 51
%A Julião, Murilo S. S.,
%A I., Ferreira Elizabeth,
%A Ferreira, Neidenêi Gomes,
%A Serrano, S. H. P.,
%@dissemination WEBSCI
%@area FISMAT